Research progress on the pharmacological mechanism of Semen ziziphi spinosae and its extract in treating insomnia
Semen ziziphi spinosae kernel can regulate the synaptic pathway of γ-aminobutyric acid (GABA) in the hypothalamus,5-hydroxytryptamine(5-HT),which can regulate the sleep-wake balance and play an anti-insomnia role in the expression of synaptic pathways,melanin-concentrating hormone ( MCH),Orexin-A and other neurotransmitters in the hypothalamus. Semen ziziphi spinosae kernel can regulate hypothalamic energy metabolism,improve liver metabolism,regulate serum metabolite secretion,improve myocardial mitochondrial function,maintain energy metabolism balance,and improve brain sleep rhythm regulation function. Semen ziziphi spinosae kernel can correct the dysfunction of HPA axis,correct the secretion of sleep-related hormones,regulate sleep structure,and play a hypnotic role. Semen ziziphi spinosae kernel can improve immune function,reduce the release of a variety of inflammatory factors,correct neuro-endocrine-immune regulatory dysfunction,and alleviate sleep disorders.
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