Medication characteristics and compatibility rules of Chinese Medical Code 5.0 against qi deficiency syndrome of stroke based on data mining
Objective To explore the medication characteristics and compatibility rules in the qi deficiency syndrome of stroke from Chinese Medical Code 5.0.Methods The ancient and modern prescriptions for qi deficiency syndrome of stroke in Chinese Medical Code 5.0 were collected.A standardized data base was established with Microsoft Office Excel 2013 software.Data mining methods,such as frequency,association rules,factors and cluster analysis were studied by SPSS Statistics 25 and SPSS Modeler 18.0 software.Results 16 kinds of Chinese medicines with frequencies over 15%were obtained in this study,the top five herbs were liquorice(70 times),ginseng(64 times),white atractylodes rhizome(50 times),Chinese angelica(43 times)and Poria cocos(41 times).Most drugs were warm,cold or neutral in nature and had a sweet,pungent or bitter taste,and the drugs mainly belong to spleen channel,lung channel and heart channel.The top six types of Chinese medicine were tonifying deficiency drugs,diaphoretic,qi-regulating drug,resolving phlegm,relieving cough,relieving asthma drugs and warming-interior drugs.50 kinds of strong correlation matching methods were obtained by correlation analysis(confidence>0.8,support>0.1).The top 5 drug pairs were Atractylodes-Poria cocos,Licorice-Dried orange peel,Poria cocos-Pinellia,Ginseng-Pinellia,Licorice-Pinellia.Cluster analysis showed that five groups were clustered.Complex network analysis showed that the core prescription consisted of 26 kinds of Chinese herbs:ginseng,pinellia,Gastrodia,Chuanxiong,Angelica,radix aucklandiae,platycodon,cooked Rehmannia,Duhuo,licorice,ginger,Baizhu,Paeoniae,radix angelicae,bamboo juice,asarum,Qianghuo,cinnamon,Poria,Parsnips,aconite,Tangerine peel,ephedra,Scutellaria,As-tragalus,Lindera aggregata,which is thecombined prescription of Liujunzi Decoction,Siwu Decoction and Jiuwei Qianghuo Decoction.Conclusion The prescriptions recorded in Chinese Medical Code for the treatment of qi deficiency syndrome of stroke present a rule of prescriptions based on reinforcing qi and nourishing blood,regulating qi and eliminating phlegm and dispelling wind and eliminating dampness,which is tonifying qi as the core,combined with the use of wind-dispelling phlegm-removing and dampness-dispelling medicine.It should be noted that qi deficiency syndrome runs through the onset of stroke.In the treatment of qi deficiency syndrome of stroke,regulating acquired qi is the key to treatment.The use of toxic traditional Chinese medicine may become a new idea for the treatment of qi deficiency syndrome of stroke.
NETL
NSTL
万方数据
