摘要
黄芪为豆科植物膜荚黄芪和蒙古黄芪干燥的根,其化学成分比较复杂,主要有效成分包括黄酮类、皂苷类、多糖类以及氨基酸类.本文从抗炎、抗氧化应激损伤、抗纤维化、抗肺肿瘤、改善呼吸肌疲劳、调节肺血管通透性、保护肺血管内皮损伤、改善肺血管重塑、调节免疫功能、增强机体抵抗力等方面对黄芪及其有效成分在肺系疾病的作用机制以及临床应用进行论述,以期为黄芪在肺系疾病的进一步研究和应用提供参考.
Abstract
Astragalus is the dried root of Astragalus Membranaceus and Astragalus Mongolica,family leguminosae,and its chemical composition is relatively complex,with the main active ingredients in-cluding flavonoids,saponins,polysaccharides,and amino acids.In this paper,we discuss the mechanism of action and clinical application of Astragalus and its active ingredients in pulmonary diseases from the functions of anti-inflammation,anti-oxidative stress injury,anti-fibrosis,anti-lung tumour,improvement of respiratory muscle fatigue,regulation of pulmonary vascular permeability,protection of pulmonary vascular endothelial injury,improvement of pulmonary vascular remodelling,regulation of immune function,and enhancement of body resistance,with the research targets of providing references to the further research and application of Astragalus in pulmonary diseases.
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