Research progress on the mechanism of salvia miltiorrhiza and its effective ingredients in the treatment of diabetic nephropathy
Salvia miltiorrhiza contains tanshinol,salvianolic acid,tanshinone and other effective ingredients,which can regulate various pathological changes of diabetic nephropathy.Many effective ingredients in Salvia miltiorrhiza can regulate blood glucose levels by regulating glucose metabolism and im-proving insulin secretion and resistance,improving blood lipid levels and regulating lipid metabolism by regulating multiple cytokines,improving renal blood flow by regulating blood flow perfusion and inhibiting thrombosis,it can act on multiple targets to reduce oxidative stress damage to the kidneys and improve an-tioxidant capacity,reducing inflammatory response by inhibiting the expression of TGF-β1 and NF-κB and regulating the PI3K/Akt signaling pathway,it can also be achieved by regulating TGF-β/Smad,HPSE/SDC1,Wnt/β-Catenin,Sirt1,NF-κB,Notch,and JAK/STAT signaling pathway to exert anti fibrotic effects,thus reducing renal damage in patients with diabetic nephropathy and playing a role in renal protection.This article reviewed the relevant research on the intervention of salvia miltiorrhiza and its effective ingredients in diabetic nephropathy in recent years,summarized the therapeutic effect of salvia miltiorrhiza and its effective ingredients on many pathological changes of diabetic nephropathy,and summarized the mechanism of action of salvia miltiorrhiza and its effective ingredients in the occurrence and development of diabetic nephropathy,providing scientific basis for clinical application of salvia miltiorrhiza in the treatment of diabetic nephropathy.
Salvia miltiorrhizadiabetic nephropathyblood sugarblood lipidsblood flowoxidative stressinflammatory responserenal fibrosisresearch progress
万方数据
维普
