Research progress on the pharmacological effects of licorice active ingredients in the prevention and treatment of asthma
Licorice active ingredients can inhibit the activation of nuclear factor kappa B(NF-κB)signaling pathway,regulate the V-type set and immunoglobulin domain 4(VSIG4)/NOD like receptor family heat protein domain related protein 3(NLRP3)inflammatory complex pathway,inhibit the activation of transforming growth factor-β 1(TGF-β1)/Smad signaling pathway,inhibit the activity of Th2 cells,and inhibit neutrophil chemotactic factor 1(CINC-1)in pancreatic tissue,mediate neutrophil in-flammatory response,reduce airway inflammatory response.The active ingredients of licorice can activate the nuclear factor E2 related factor 2(Nrf2)/heme oxygenase-1(HO-1)signaling pathway,reduce oxidative stress response.The active ingredients of licorice can inhibit the activity of TGF-β 1/Smad signaling pathway,promote apoptosis of pulmonary airway smooth muscle cells,delay airway remodeling,and protect lung function.The active ingredients of licorice can inhibit the formation of specific IgE and IgG,activate trans gel protein-2,prevent smooth muscle contraction,and reduce airway hyperreactivity.The active ingredients of licorice can regulate the functions of Th1/Th2 cells and Treg cells,and improve immune function.This study summarized the pharmacological effects of licorice active ingredients on asthma by recent research reports,providing references for the treatment of asthma.
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