Research progress on mechanism of TCM prevention and treatment of atherosclerosis based on reg-ulation of pathways related to macrophage polarization
The polarization of macrophages under the influence of different microenvironments plays an important role in the formation and development of atherosclerosis.How to regulate the polarization direction of M1/M2 macrophages to interfere with inflammation has become a hot research topic in the prevention and treatment of atherosclerosis.In recent years,a large number of animal experiments and cell experiments have found that the mechanism of traditional Chinese medicine(TCM)regulating macrophage polarization to prevent atherosclerosis is closely related to multiple signaling pathways and cytokines.Based on the signaling pathway,this paper summarized the relationship between several signaling pathways such as JAK-STAT,Notch,MAPKs,PI3K/Akt,NF-κB,AMPK-mTORC1 and macrophage polarization,and the monomers and compounds of TCM can inhibit the inflammatory response by inhibiting the relevant signaling pathways,thereby stabilizing and slowing down the progression.To provide theoretical references for the treatment of atherosclerosis by targeted regulation of macrophage polarization by TCM.
atherosclerosismacrophage polarizationtraditional Chinese medicinesignal pathwaycytokinesanti-inflammatoryaction mechanismresearch progress
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