Objective To summarize the nursing experience of the lower limb osteofascial compartment syndrome(OCS)complicated with amniotic fluid embolism treated with extracorpored(ECNO).Method The main nursing points included:(1)nursing care for EC MO support therapy;(2)Early identification and evaluation of OCS;(3)Ap-plication of VSD negative pressure sealing drainage technology and observation nursing beside the bed;(4)ICU dia-ries helped patients establish a mindset for rehabilitation,with support from family and family members,and inter-disciplinary collaboration to develop rehabilitation plans.Result After 133 d of careful care,the patient was success-fully discharged from the hospital.Conclusion Timely and effective nursing can effectively shorten the existing hospi-talization time,enable patients to smoothly recover from daily life,and improve the stability,muscle strength,physical strength,and balance ability required for daily life after the rehabilitation of the affected limb with OCS.