Objective To comprehensively evaluate the application status of evidence related to early fluid resusci-tation management in patients with acute pancreatitis,formulate review indicators,and analyze barrier factors and promoting factors.Methods With the knowledge transformation framework(KTA)as the theoretical framework,clinical problems were identified,evidence-based teams were established,the evidence was systematically searched,evaluated,and integrated,and review indicators and clarify review methods were developed.From May 1 to October 1,2022,clinical review was carried out,obstacles and promoting factors were analyzed according to the review re-sults,and action strategies were formulated.Results Totally 15 pieces of best evidence were included and 16 clinical review indicators were formulated,of which there were 15 indicators with the compliance rate of<60%.By analy-zing the review results one by one and the main obstacles factors were found out:The evidence was beyond reach,which changed the previous work mode;Relevant knowledge and skills of potential adopters needed to be improved,and evidence conversion would increase the workload of nurses;The practice environment lacked the equipment nee-ded for evidence-based processes and changes,and the multidisciplinary communication channels were not smooth.The main promoting factors were as followed:Our hospital was the evidence application base of evidence-based nurs-ing in Fudan University,and had successfully transformed many evidence-based projects;The transformation de-partment was a key specialty in Jiangsu province and had all kinds of talent reserves needed for transformation,and the department had a good atmosphere of medical and nursing cooperation,and the majority of young nurses had strong learning ability.Conclusion There is a big gap between the clinical practice and the best evidence of early fluid resuscitation management for AP patients.Through in-depth analysis of obstacle factors,corresponding action strat-egies were formulated to promote the effective conversion of evidence to clinical practice,and to ensure the safety and rationality of early fluid resuscitation in patients with AP.