Meta-analysis of risk factors for stroke in patients with maintenance hemodialysis
Objective To systematically evaluate the risk factors of stroke in maintenance hemodialysis(MHD)patients.Methods Researches on the risk factors of stroke in MHD patientswere searched by computer in CNKI,VIP,Wanfang,CMB,The Cochrane Library,Web of Science,PubMed,and Embase databases,and meta-analysis was performed using RevMan 5.4 software,and the search period was from the establishment of the database up to May 31,2022.Results A total of 27 literatures were finally included,with the sample size of 12,247 cases.The re-sults of meta-analysis showed that diabetes mellitus(OR=2.52,95％CI was 1.95-3.27,P＜0.05),age(OR=1.15,95％CI was 1.08-1.21,P＜0.05),hypertension(OR=2.15,95％CI was 1.61-2.88,P＜0.05),dyslipi-demia(OR=1.88,95％CI was 1.43-2.46,P＜0.05),increased systolic blood pressure before dialysis(OR=1.16,95％CI was 1.07-1.25,P＜0.05),age of dialysis(OR=1.67,95％CI was 1.18-2.35,P＜0.05),in-creased diastolic blood pressure before dialysis(OR=1.23,95％CI was 1.06-1.43,P＜0.05),atrial fibrillation(OR=2.17,95％CI was 1.83-2.58,P＜0.05),coronary heart disease(OR=7.38,95％CI was 4.22-12.91,P＜0.05),amino terminal brain natriuretic peptide precursors increased after transdialysis(OR=3.88,95％CI was 1.60-9.40,P＜0.05),homocysteine Hcy≥15 μmol/L(OR=3.10,95％CI was 1.62-5.92,P＜0.05),and pre-vious cerebrovascular events(OR=3.22,95％CI was 1.26-8.26,P＜0.05)were risk factors for stroke in MHD patients.Conclusion There are many risk factors for stroke in MHD patients,and medical staff should be familiar with the risk factors and preventive measures of stroke,and give individualized intervention as soon as possible to re-duce the risk of stroke in dialysis patients.
万方数据
维普
