The clinical value of plasma microRNA-216 for early identifying the severity of acute pancreatitis
Objective To investigate the value of plasma microRNA-216 (miR-216) in patients with acute pancreatitis as a clinical biomarker to early identify severe acute pancreatitis (SAP). Methods Patients with acute pancreatitis who admitted to the hospital within 48 hours after the onset of disease between September and November 2014 were enrolled in this study. Plasam and clinical data of all the patients were collected. MiR-216 in the plasma was detected using quantitative real time-polymerase chain reaction. Results A total of 25 patients were enrolled. The Ct value of plasma miR-216 in SAP patients (32.40±1.43) was significantly upregulated than mild acute pancreatitis (MAP) (35.85±1.91, P＜0.05) and moderately severe acute pancreatitis (MSAP) patients (35.90±2.44, P＜0.05), respectively. The area under receiver operating characteristic curve for plasma miR-216 in predicting SAP was 0.792 (P＜0.05), which did not differ much from other conventional parameters such as C-reactive protein, urinary nitrogen, and cytokines (P＞0.05). Conclusion Plasma miR-216 is significantly upregulated in SAP patients compared with MAP and MSAP, but it shows no inferior efficiency than the investigated conventional predictors in predicting SAP.
NETL
NSTL
万方数据
维普
