摘要
1型糖尿病(type 1 diabetes mellitus,T1DM)是胰岛β细胞被破坏后导致胰岛素绝对缺乏的自身免疫性疾病.肠道菌群及其代谢产物可通过破坏胰岛β细胞、增加胰岛素抵抗、增加肠道通透性、干扰免疫反应等方式促进T1DM的病情进展.因此肠道菌群移植在未来有望成为预防和治疗T1DM的新方法.该文主要探讨肠道菌群移植在T1DM中应用的可能途径,包括保护胰岛β细胞、改善胰岛素抵抗、降低肠道通透性、调节免疫反应.
Abstract
Type 1 diabetes mellitus(T1DM)is an autoimmune disease in which pancreatic β cells are destroyed,resulting in an absolute lack of insulin.Intestinal microbiota and its metabolites can promote the progression of T1DM by destroying pancreatic β cells,increasing insulin resistance,increasing intestinal permeability,interfering with immune response.Therefore,fecal microbiota transplantation is expected to become a new method for preventing and treating T1DM in the future.This article mainly explores possible pathways for the application of fecal microbiota transplantation in T1DM,including protection of pancreatic β cells,improving insulin resistance,reducing intestinal permeability,and regulating immune responses.
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