Causal relationship between asthma and gastroesophageal reflux disease based on two-sample Mendelian randomization
Objective To evaluate the potential causal relationship between asthma and the risk of gastroesophageal reflux disease(GERD)using a two-sample Mendelian randomization study.Methods A large sample of genome-wide association study was used to summarize the data,and the genetic loci[single nucleotide polymorphisms(SNPs)]closely related to asthma were selected as instrumental variables,and Mendelian randomization analysis was conducted by inverse variance weighting,weighted median and MR-Egger method,respectively.At the same time,the multi-effect of MR-Egger was detected and the sensitivity analysis was carried out by Leave-one-out method to ensure the robustness of the results.Results A total of 77 SNPs closely related to asthma were selected as instrumental variables.The results of inverse variance weighted analysis showed a significant positive correlation between asthma and the occurrence of gastroesophageal reflux disease[odds ratio(OR)=1.044,95％confidence interval(CI)(1.006,1.083),P=0.024].Weighted median results showed similar causality[OR=1.075,95％CI(1.021,1.133),P=0.006].The MR-Egger regression results showed that there was a positive correlation between asthma and GERD,but there was no statistical significance[OR=1.080,95％CI(0.983,1.187),P=0.115].The heterogeneity test results showed that there was no heterogeneity in the causal relationship between asthma and GERD(P＞0.05).The results of the horizontal pleiotropy test showed that there was no horizontal pleiotropy in SNPs(P＞0.05).The results of the retention test showed that no SNPs with significant impact on the results were detected.Conclusion There is a positive causal relationship between asthma and GERD.
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