Research progress of matrix metalloproteinase in pulmonary tuberculosis
Tuberculosis is a chronic infectious diseases caused by Mycobacterium tuberculosis.Its high morbidity and mortality have posed a serious threat to global public health.Matrix metalloproteinase(MMP)is a proteolytic enzyme involved in regulating extracellular matrix degradation and remodeling.MMP is highly expressed in pulmonary tuberculosis,and its expression is regulated by genes,epigenetic modifications,cellular signaling pathways,immune regulation,and cellular environment.MMP is a potential target for the treatment of pulmonary tuberculosis.Therefore,this article summarizes the expression and related mechanisms of MMP in pulmonary tuberculosis,aiming to provide a reference for the diagnosis and treatment of pulmonary tuberculosis.
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