基质金属蛋白酶在肺结核中的研究进展
Research progress of matrix metalloproteinase in pulmonary tuberculosis
谭玲 1王静静 2马雪 3雷丰丰4
作者信息
- 1. 兰州大学第一临床医学院(兰州 730000)
- 2. 甘肃中医药大学第一临床医学院(兰州 730000)
- 3. 江苏大学医学院(江苏镇江 212000)
- 4. 兰州大学第一临床医学院(兰州 730000);甘肃省人民医院呼吸与危重症医学科(兰州 730000)
- 折叠
摘要
肺结核是一种由结核分枝杆菌引起的慢性感染性疾病,其高患病率、高死亡率已对全球公共卫生构成严重威胁.基质金属蛋白酶(matrix metalloproteinase,MMP)是一类参与调节细胞外基质降解和重塑的蛋白水解酶.MMP在肺结核中高表达,其表达受基因、表观遗传修饰、细胞信号通路、免疫调节及细胞环境共同调控,MMP是肺结核治疗的潜在靶点.因此,该文总结了 MMP在肺结核中的表达情况及相关作用机制,旨在为肺结核的诊治提供参考依据.
Abstract
Tuberculosis is a chronic infectious diseases caused by Mycobacterium tuberculosis.Its high morbidity and mortality have posed a serious threat to global public health.Matrix metalloproteinase(MMP)is a proteolytic enzyme involved in regulating extracellular matrix degradation and remodeling.MMP is highly expressed in pulmonary tuberculosis,and its expression is regulated by genes,epigenetic modifications,cellular signaling pathways,immune regulation,and cellular environment.MMP is a potential target for the treatment of pulmonary tuberculosis.Therefore,this article summarizes the expression and related mechanisms of MMP in pulmonary tuberculosis,aiming to provide a reference for the diagnosis and treatment of pulmonary tuberculosis.
关键词
基质金属蛋白酶/肺结核/调节机制Key words
Matrix metalloproteinase/pulmonary tuberculosis/regulatory mechanism引用本文复制引用
出版年
2024
NETL
NSTL
万方数据