术前血小板与淋巴细胞比值与胰腺导管腺癌患者预后关系的Meta分析
Relationship between preoperative platelet-to-lymphocyte ratio and prognosis in patients with pancreatic ductal adenocarcinoma:a meta-analysis
何栋 1樊万里 1张树泽 1赵斌 1程志斌1
作者信息
- 1. 兰州大学第二医院普通外科(兰州 730030)
- 折叠
摘要
目的 系统评价胰腺导管腺癌(pancreatic ductal adenocarcinoma,PDAC)患者术前血小板与淋巴细胞比值(platelet-to-lymphocyte ratio,PLR)与其预后的关系.方法 检索中国知网、维普、中国生物医学文献数据库、万方、PubMed、Embase、Web of Science、Cochrane Library中关于术前PLR与PDAC患者预后关系的研究,检索时限从建库至2023年12月.采用RevMan 5.3软件进行Meta分析.结果 共纳入7项研究,包括1273例患者.Meta分析结果显示,术前高PLR的PDAC患者术后总生存期[风险比(hazard ratio,HR)=1.69,95％置信区间(confidence interval,CI)(1.24,2.30)]与无病生存期[HR=1.83,95％CI(1.49,2.24)]均缩短(P＜0.05).亚组分析结果显示,PLR临界值＜200时,术前高PLR与总生存期缩短有关(HR=1.91,P＜0.05),而PLR临界值≥200时,术前PLR与总生存期无明显相关性(P＞0.05);随访＜3年时,术前高PLR与总生存期缩短有关(HR=2.05,P＜0.05),而随访≥3年时,术前PLR与总生存期无明显相关性(P＞0.05).结论 当前证据显示,术前高PLR可能是PDAC患者预后不良的危险因素.
Abstract
Objective To systematically review the relationship between preoperative platelet-to-lymphocyte ratio(PLR)and prognosis in patients with pancreatic ductal adenocarcinoma(PDAC).Methods Studies on the relationship between preoperative PLR and prognosis of PDAC patients were retrieved from China National Knowledge Infrastructure,Chongqing VIP,SinoMed,Wanfang,PubMed,Embase,Web of Science,and Cochrane Library,with a search period from databases establishment to December 2023.A meta-analysis was conducted using RevMan 5.3 software.Results A total of 7 studies were included,including 1273 patients.The meta-analysis results showed that the postoperative overall survival[hazard ratio(HR)=1.69,95％confidence interval(CI)(1.24,2.30)]and disease-free survival[HR=1.83,95％CI(1.49,2.24)]of PDAC patients with high preoperative PLR were shortened(P＜0.05).The results of subgroup analysis showed that when the cut off of PLR was＜200,preoperative high PLR was associated with shortened overall survival(HR=1.91,P＜0.05),but when the cut off of PLR was ≥200,there was no significant correlation between preoperative PLR and overall survival(P＞0.05).When followed up for＜3 years,preoperative high PLR was associated with shortened overall survival(HR=2.05,P＜0.05),but when followed up for ≥3 years,there was no significant correlation between preoperative PLR and overall survival(P＞0.05).Conclusion Current evidence suggests that preoperative high PLR may be a risk factor for poor prognosis in PDAC patients.
关键词
胰腺导管腺癌/预后/血小板与淋巴细胞比值/Meta分析Key words
Pancreatic ductal adenocarcinoma/prognosis/platelet-to-lymphocyte ratio/meta-analysis引用本文复制引用
出版年
2024
NETL
NSTL
万方数据