局部晚期直肠癌新辅助治疗反应评估及预测研究进展
Research progress on response evaluation and prediction of neoadjuvant therapy for locally advanced rectal cancer
梁玉汶 1杜小波1
作者信息
- 1. 川北医学院临床医学系(四川南充 637000);绵阳市中心医院肿瘤科(四川绵阳 621000);四川省放射与治疗临床医学研究中心(四川绵阳 621000)
- 折叠
摘要
局部晚期直肠癌的标准治疗方式为新辅助放化疗联合手术治疗,但经相同治疗方案后的患者表现出较大的结局差异.对于新辅助治疗反应良好的患者,可谨慎选择"等待&观察"的策略,以避免手术及其他并发症.因此,准确评估局部晚期直肠癌患者新辅助治疗后肿瘤的反应可以更好地制定个性化治疗策略.目前的研究发现,血液样本检测、体格检查、内镜、影像学检查及人工智能在评估新辅助治疗反应方面各有利弊.因此,该文对不同临床工具在评估及预测局部晚期直肠癌新辅助治疗反应的应用研究成果进行了综述,并对未来发展方向进行了展望.
Abstract
The standard treatment for locally advanced rectal cancer is neoadjuvant chemoradiotherapy combined with surgery,but patients after the same treatment regimen show a large difference in outcomes.For patients with good response to neoadjuvant therapy,the waiting & observation scheme can be selected to avoid surgery and other complications.Therefore,accurate assessment of the response of patients with locally advanced rectal cancer after neoadjuvant therapy can better develop personalized treatment strategies.Current studies have found that blood sample detection,endoscopy,imaging examination and artificial intelligence have their own advantages and disadvantages in evaluating the response of neoadjuvant therapy.Therefore,this article reviews the application of different clinical tools in evaluating and predicting the response of neoadjuvant therapy for locally advanced rectal cancer,and looks forward to the future development direction.
关键词
直肠癌/新辅助治疗/反应/评估Key words
Rectal cancer/neoadjuvant therapy/response/assessment引用本文复制引用
出版年
2024
NETL
NSTL
万方数据