摘要
铁死亡作为新型程序性细胞死亡形式,影响着肝癌的发生、进展与治疗.该文对铁死亡的发现、特征、调控机制、抑制剂与诱导剂及检测指标进行了系统的总结与分析,同时概述了铁死亡对肝癌进展、转移、治疗与预后的影响,最后得出结论,靶向铁死亡治疗肝癌是有希望的治疗策略.
Abstract
Ferroptosis,as a new form of programmed cell death,affects the occurrence,progression and treatment of liver cancer.In this paper,the discovery,characteristics,regulatory mechanisms,inhibitors,inducers,and detection indicators of ferroptosis were systematically summarized and analyzed,and the effects of ferroptosis on the progression,metastasis,treatment,and prognosis of liver cancer were summarized.Finally,it was concluded that targeting ferroptosis is a promising treatment strategy for liver cancer.
基金项目
国家自然科学基金(81973733)
深圳市科技计划项目(JCYJ20220530172812028)
NETL
NSTL
万方数据