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铁死亡及其在肝癌中的研究进展

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铁死亡作为新型程序性细胞死亡形式,影响着肝癌的发生、进展与治疗.该文对铁死亡的发现、特征、调控机制、抑制剂与诱导剂及检测指标进行了系统的总结与分析,同时概述了铁死亡对肝癌进展、转移、治疗与预后的影响,最后得出结论,靶向铁死亡治疗肝癌是有希望的治疗策略.
Research progress of ferroptosis and its role in liver cancer
Ferroptosis,as a new form of programmed cell death,affects the occurrence,progression and treatment of liver cancer.In this paper,the discovery,characteristics,regulatory mechanisms,inhibitors,inducers,and detection indicators of ferroptosis were systematically summarized and analyzed,and the effects of ferroptosis on the progression,metastasis,treatment,and prognosis of liver cancer were summarized.Finally,it was concluded that targeting ferroptosis is a promising treatment strategy for liver cancer.

Ferroptosisliver cancermechanismlipid peroxidationiron metabolismresearch progress

刘博文、李晓斌、马贵萍、仪凡、李峰、孙童、庞旭、胡世平

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北京中医药大学深圳医院(龙岗)肝病科(广东深圳 518172)

首都医科大学附属北京中医医院皮肤科(北京 100010)

铁死亡 肝癌 机制 脂质过氧化 铁代谢 研究进展

国家自然科学基金深圳市科技计划项目

81973733JCYJ20220530172812028

2024

华西医学
四川大学华西医院

华西医学

CSTPCD
影响因子:0.744
ISSN:1002-0179
年,卷(期):2024.39(7)
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