急性白血病脂质代谢的最新研究进展
Recent advances in lipid metabolism of acute leukemia
董少娟 1崔梦莹 1何丽 1鲍颖 1朱丹霞 2吴骏 2陈烨1
作者信息
- 1. 湖北医药学院附属襄阳市第一人民医院血液内科(湖北襄阳 441000)
- 2. 苏州大学附属第三医院/常州市第一人民医院肿瘤内科(江苏常州 213003)
- 折叠
摘要
急性白血病患者治疗效果不佳,生存期短,主要原因之一是缺乏有效的早期诊断和治疗靶标.脂质代谢重编程满足了快速增殖和分裂肿瘤细胞的物质和能量需求,并且与急性白血病的侵袭性、复发、化学治疗耐药性有关.该文综述了白血病细胞脂质代谢重编程的致癌和化学治疗耐药机制,并总结了靶向脂肪酸代谢途径的最新发现,旨在为细胞内脂肪酸代谢在急性白血病发生发展中的作用提供新的视角,期望能为其耐药机制的阐明以及相应靶向治疗的研发提供理论依据.
Abstract
The poor treatment effect and short survival period of patients with acute leukemia are mainly due to the lack of effective early diagnosis and treatment targets.Lipid metabolism reprogramming meets the material and energy requirements for rapid proliferation and division of tumor cells,and is associated with the invasiveness,recurrence,and chemotherapy resistance of acute leukemia.This article reviews the carcinogenic and chemotherapy resistance mechanisms of lipid metabolism reprogramming in leukemia cells,and summarizes the latest findings on targeted fatty acid metabolism pathways,aiming to provide a new perspective on the role of intracellular fatty acid metabolism in the occurrence and development of acute leukemia.It is expected to provide a theoretical basis for the elucidation of its resistance mechanism and the development of corresponding targeted therapies.
关键词
急性白血病/脂质代谢重编程/靶向代谢/靶向治疗/化学治疗耐药Key words
Acute leukemia/lipid metabolism reprogramming/targeted metabolism/targeted therapy/chemotherapy resistance引用本文复制引用
出版年
2024
NETL
NSTL
万方数据