Clinical characteristics analysis of hepatitis B virus infected individuals with high hepatitis B virus pregenomic RNA
Objective To analyze the clinical characteristics of individuals with high hepatitis B virus(HBV)pregenomic RNA(pgRNA),and further explore the value of pgRNA in the management of patients with chronic hepatitis B.Methods From December 1st,2020 to April 1st,2022,chronic hepatitis B patients who had been treated with nucleotide analogues for a long time and followed up in the Hepatitis Clinic of the Center of Infectious Diseases,West China Hospital,Sichuan University were included,and the clinical characteristics of chronic hepatitis B patients with high pgRNA were analyzed and summarized.Results A total of 107 patients were included.Male patients accounted for 66.4％,with an average age of 44.02 years.There were no statistically significant differences in gender,age,aspartate transaminase,alanine transaminase,γ-glutamyl transferase,HBV surface antigen,proportion of patients with HBV e antigen ≥0.1 U/mL,HBV DNA,and alpha fetoprotein between the high and low pgRNA groups(P＞0.05).The proportion of patients with HBV surface antigen＜100 U/mL in the high pgRNA group was lower than that in the low pgRNA group(4.4％vs.22.6％,P＜0.05).Conclusion The proportion of chronic hepatitis B patients with high pgRNA whose HBV surface antigen≥ 100 U/mL is higher.
Hepatitis B virus pregenomic RNAchronic hepatitis Bserological marker
NETL
NSTL
万方数据
