在白血病细胞中普遍存在着Janus激酶(Janus kinase,JAK)-信号传导和转录激活因子(signal transduction and activator of transcription,STAT)信号通路的持续激活,该通路在急性白血病(acute leukemia,AL)中占据了重要地位.JAK2/JAK1基因突变在急性髓系白血病和急性淋巴细胞白血病中均有发现,并可能对疾病治疗和总体预后存在影响.在STAT家族成员中,STAT3和STAT5被证明是AL的关键影响因素.这些基因突变都可能为AL的治疗提供新靶点与新思路.该文就有关JAK-STAT信号通路及相关基因突变与AL的研究进展作一综述.
Research progress of Janus kinase-signal transduction and activator of transcription signaling pathway related gene mutations in acute leukemia
Continuous activation of Janus kinase(JAK)-signal transduction and activator of transcription(STAT)signaling pathway is prevalent in leukemia cells,and it has been found that this pathway plays an important role in acute leukemia(AL).JAK2/JAK1 gene mutations are found in both acute myelocytic leukemia and acute lymphoblastic leukemia and may have implications for the treatment and overall prognosis of the disease.Among the STAT family members,STAT3 and STAT5 proved to be key factors in AL.These gene mutations may provide new targets and new ideas for the treatment of AL.This article provides a review of the research progress of JAK-STAT signaling pathway,related gene mutations and AL.
Janus kinase-signal transduction and activator of transcription signaling pathwayacute leukemiaSH2B3
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NSTL
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