长期使用抗菌药物与肾癌风险的关系
Relationship between long-term use of antimicrobial agent and risk of kidney cancer
刘嘉旎 1陈湘钰 2代小雨3
作者信息
- 1. 川北医学院临床医学院(四川南充 637100);电子科技大学医学院附属绵阳医院·绵阳市中心医院肾内科(四川绵阳 621000)
- 2. 电子科技大学医学院附属绵阳医院·绵阳市中心医院肾内科(四川绵阳 621000)
- 3. 电子科技大学医学院附属绵阳医院·绵阳市中心医院肾内科(四川绵阳 621000);剑阁县人民医院(四川广元 628399)
- 折叠
摘要
肾癌是一种常见的恶性肿瘤,是最致命的泌尿生殖系统癌症.鉴于肾癌的发病率上升,对其可调控的危险因素进行及时干预十分重要.抗菌药物在全球范围内被广泛应用,近年来一些研究发现长期使用抗菌药物与肾癌发生风险增加有关,其机制可能涉及抗菌药物本身肾毒性和肠道菌群失调等多个环节.该文综述了长期使用抗菌药物与肾癌风险的关系,并探讨其中可能的机制,旨在了解长期使用抗菌药物对肾癌发生风险的影响,为肾癌的早期预防和抗菌药物的合理使用提供更多参考.
Abstract
Renal cancer is a common malignant tumor and the deadliest cancer of the urinary and reproductive system.Given the increasing incidence rate of kidney cancer,timely intervention of its controllable risk factors is crucial.Antimicrobial agent is widely used worldwide,and in recent years,some studies have found that long-term use of antimicrobial agent is associated with an increased risk of kidney cancer.The mechanism may involve multiple factors such as nephrotoxicity of antimicrobial agent and intestinal flora imbalance.This article reviews the relationship between long-term use of antimicrobial agent and risk of kidney cancer,and explores possible mechanisms,to understand the impact of long-term use of antimicrobial agent on the risk of kidney cancer,and to provide more references for early prevention of kidney cancer and rational use of antimicrobial agent.
关键词
抗菌药物/肾癌/机制Key words
Antimicrobial agent/kidney cancer/mechanism引用本文复制引用
出版年
2024
NETL
NSTL
万方数据