Objective To investigate the potential causal relationship between chronic rhinosinusitis(CRS)and chronic obstructive pulmonary disease(COPD)using a two-sample two-way Mendelian randomization(MR)approach.Methods In the forward study,single nucleotide polymorphisms(SNPs)closely associated with CRS were selected as instrumental variables from publicly available genome-wide association studies datasets,with COPD as the outcome variable;conversely,in the reverse study,SNPs closely associated with COPD were selected as instrumental variables,with CRS as the outcome variable.MR analysis was conducted using three regression models:inverse variance weighted(IVW),MR-Egger regression analysis,and weighted median(WME)to assess the causal relationship between CRS and COPD.Cochran's Q statistic,MR-Egger intercept,MR-PRESSO,and"leave-one-out"methods were employed to test for heterogeneity and horizontal pleiotropy,thereby evaluating the stability and reliability of the MR results.Results A total of 14 SNPs closely associated with CRS were included in the forward study;the IVW-fixed effects analysis indicated that CRS may increase the risk of developing COPD[odds ratio=1.003,95％confidence interval(1.002,1.004),P＜0.001],which was confirmed by the WME method,while the MR-Egger regression method did not show a causal link between CRS and COPD.Heterogeneity test(IVW result:Cochran's Q=7.910,P=0.849;MR-Egger regression result:Cochran's Q=7.450,P=0.827),MR-Egger intercept method(P=0.510),MR-PRESSO test(P=0.917),and"leave-one-out"method showed that the MR analysis results were reliable.In the reverse study,a total of 12 SNPs related to COPD were included as instrumental variables;MR analysis did not support the notion that COPD would increase the risk of CRS(P＞0.05).Heterogeneity test(IVW result:Cochran's Q=5.947,P=0.877;MR-Egger regression result:Cochran's Q=5.937,P=0.821),MR-Egger intercept method(P=0.921),MR-PRESSO test(P=0.875),and"leave-one-out"analysis method showed that the MR analysis results were reliable.Conclusions There is a potential causal association between CRS and COPD,and CRS may increase the risk of developing COPD.But there is no evidence to suggest that COPD increases the risk of CRS.
关键词
慢性鼻窦炎/慢性阻塞性肺疾病/孟德尔随机化/因果关联
Key words
Chronic rhinosinusitis/chronic obstructive pulmonary disease/Mendelian randomization/causal association
维普
万方数据