Clinical effectiveness and safety of tranexamic acid in arthroscopic rotator cuff repair:a meta-analysis
Objective To evaluate the clinical effectiveness and safety of tranexamic acid(TXA)in arthroscopic rotator cuff repair by meta-analysis.Methods Randomized controlled trials evaluating the clinical effectiveness and safety of TXA use in the perioperative period of arthroscopic rotator cuff repair were identified from the Cochrane Library,PubMed,Embase,VIP Chinese Science and Technology Periodical Database,Chinese National Knowledge Infrastructure,and Wanfang database,with a search time span from the inception of the database to August 2024.Meta-analysis was conducted using RevMan 5.3 software,and mean difference(MD)and risk difference(RD)were used as measures of effect size.Results A total of 7 randomized controlled trials were included.Meta-analysis demonstrated significant differences in good visual clarity[MD=9.10,95％confidence interval(CI)(4.05,14.15),P=0.0004]and operative time[MD=-12.07 min,95％CI(-17.21,-6.93)min,P＜0.00001].There was no significant difference in mean arterial pressure[MD=-1.08 mm Hg(1 mm Hg=0.133 kPa),95％CI(-3.13,0.98)mm Hg,P=0.30]or adverse event rate[RD=0.02,95％CI(-0.01,0.06),P=0.22]between the two groups.Conclusion TXA is effective and safe in enhancing visual clarity and significantly reducing operative time in arthroscopic rotator cuff repair,without increasing the incidence of adverse events.
万方数据
维普
