Thyroid dysfunction and osteoporosis:a bidirectional,two-sample Mendelian randomization study
Objective To explore the potential causal relationship between thyroid dysfunction and osteoporosis(OP)through bidirectional two-sample Mendelian randomization(MR)analysis to provide genetic evidence for the risk association between thyroid dysfunction and OP,and provide reference for early prevention and treatment of OP.Methods Causal relationships were estimated based on data from genome-wide association studies for hypothyroidism(n=410141),hyperthyroidism(n=460 499),Hashimoto thyroiditis(n=395 640),and OP(n=212 778).The inverse variance weighted method was used as the main analysis method,and the other four methods were used as the supplementary analysis methods to evaluate the causal effect of thyroid dysfunction and OP.Results The results of inverse variance weighted method showed that hypothyroidism[odds ratio(OR)=1.097,95％confidence interval(CI)(1.017,1.183),P=0.017],hyperthyroidism[OR=1.089,95％CI(1.000,1.186),P=0.049]and Hashimoto thyroiditis[OR=1.190,95％CI(1.054,1.343),P=0.005]were positively correlated with the causal effect of OP.The results of reverse MR analysis did not support that OP would increase the risk of hypothyroidism,hyperthyroidism or Hashimoto thyroiditis(P＞0.05).In the bidirectional MR analyses,there was no heterogeneity in Cochran Q detection,MR-Egger intercept test results showed that there was no horizontal pleotropy,and the leave-one-out method analysis results showed that the MR analysis results were reliable.Conclusion Hypothyroidism,hyperthyroidism,and Hashimoto thyroiditis increase the risk of OP,while OP is not found to increase the risk of thyroid dysfunction in reverse studies.
万方数据
维普
