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大麻二酚治疗精神障碍的机制与临床研究进展

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精神障碍是一类行为、情绪、认知或思维紊乱的疾病,导致个体产生痛苦和社会功能障碍,是全球十大疾病负担之一。大麻二酚(cannabidiol,CBD)是大麻的主要成分之一,具有较高的安全性和耐受性,是药物研究的热点。CBD具有广泛的治疗效果,研究发现CBD具有抗成瘾、抑郁、焦虑和应激等神经精神效应,是治疗精神障碍的候选药物之一。该文总结了 CBD治疗主要精神障碍的机制和临床研究进展,以期为CBD相关化合物治疗精神障碍提供有益的参考。
Mechanism and clinical research progress of cannabidiol for mental disorders
Mental disorders are a type of behavioral,emotional,cognitive,or thinking disorder that cause pain and social dysfunction,and are one of the top ten global disease burdens.Cannabidiol(CBD)is one of the main components of cannabis,with high safety and tolerability,and is a hot topic in drug research.CBD has a wide range of therapeutic effects,and research has found that CBD has neuropsychiatric effects such as anti-addiction,anti-depression,anti-anxiety,and anti-stress,making it one of the candidate drugs for mental disorders.This article summarizes the mechanism and research progress of CBD for major mental disorders,in order to provide useful references for CBD-related compounds in the treatment of mental disorders.

Cannabidiolmental disorderstreatmentmechanisms of action

徐荟芳、况伟宏、李进

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四川大学华西医院心理卫生中心(成都 610041)

成都市第四人民医院急性精神科(成都 610036)

大麻二酚 精神障碍 治疗 作用机制

2024

华西医学
四川大学华西医院

华西医学

CSTPCD
影响因子:0.744
ISSN:1002-0179
年,卷(期):2024.39(10)