高效液相色谱法测定奥拉西坦有关物质的方法研究
Determination of Oxiracetam and its Related Substances via HPLC
常悦 1毛远湖 2张毅 2王建塔 2汤磊1
作者信息
- 1. 贵阳医学院医药卫生管理学院,贵州贵阳 550004
- 2. 贵阳医学院药学院,贵州贵阳 550004
- 折叠
摘要
建立HPLC法检测奥拉西坦有关物质的方法.采用Agilent UST0014616氨基柱(4.6 mm ×250 mm,5μm);V(乙腈)∶V(水)=95∶5为流动相;检测波长220 nm,柱温30℃.经专属性试验奥拉西坦峰与相邻有关物质峰分离度良好,精密度、重复性、稳定性结果良好,可简便、快速、有效地检测奥拉西坦有关物质.
Abstract
To establish an HPLC method for the analysis related substances in Oxiracetam.samples were analyzed on Agilent UST0014616 (4.6 mm × 250 mm,5 μm).The mobile phase consisted of V(acetonitrile) ∶ V(water) =95∶ 5.The detection wavelength was 220 nm and the column temperature was 30 ℃.The precision,repeatability and solution stability are reliable and related substances could be well separated from the impurities.This method is accurate and fast,and can be used for the quality control of Oxiracetam.
关键词
奥拉西坦/有关物质/HPLCKey words
Oxiracetam/related substance/HPLC引用本文复制引用
出版年
2014
国家科技期刊平台
NSTL
维普
万方数据