摘要
以1,2:5,6-氧-二异亚丙基-α-D-呋喃葡萄糖为原料,依次通过苄基保护、脱保护、甲磺酰化、酯交换、环氧化、水解重排并乙酰化得到标题化合物,总产率68.2％.该方法操作简便,适宜工业化.
Abstract
Starting from 1,2:5,6-Di-O-isopropylidene-alpha-D-glucofuranose,the fondaparinux sodium intermediate compound,1,2,4,6-O-acetyl-3-O-benzyl-L-idonic was obtained by seven steps reaction such as benzyl protection,deprotection,mesylation,epoxidation,transesterification,hydrolysis rearrangement,and acetylation successively.The total yield was 68.2％.The process is simple and suitable for industrial production.
基金项目
贵州省国际科技合作计划项目(黔科合外G字2013-7025)
贵州省高等学校创新能力提升计划(黔教合协同创新字201304)
国家重大科学仪器设备开发专项(2011YQ12003506)
国家科技期刊平台
NSTL
维普
万方数据