Tandem cyclization reaction catalyzed by copper had been widely concerned by researchers in synthetic chemistry due to its mild conditions,high atomic economy,and high reaction efficiency.Tandem cyclization reactions catalyzed by copper disclosed in recent years were reviewed,so that more precision and more flexible understanding as well as extensive expansion could be achieved.According to the valence state of the copper catalytic center in the reaction and the participation degree of copper salt,the single cuprous salt,cuprous salt co-participation,single bivalent copper salt catalysis and bivalent copper salt co-participation tandem cyclization reactions were introduced respectively.According to the requirements of green chemistry,ligands involved in copper catalyzed reaction and the possibility of reaction expansion,the research hotspot and direction of copper catalyzed tandem cyclization reaction in the future are proposed.
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