Two-dimensional metal-organic frame materials(2D-MOFs)have the advantages of large specific surface area,small thickness,full exposure of active sites,and minimal mass transfer resistance.Their application in high-performance liquid chromatography(HPLC)can theoretically increase the number of column plates and improve its separation efficiency,showing unique application value in the chiral separation field.Two-dimensional chiral metal-organic framework nanosheets(2D-CMOFs)were prepared by modifying the chiral molecules L-hydroxyproline and D-(+)-glucose onto NH2-Ni/Co MOFs and Zn-NH2-BDC MOFs,respectively.The chiral stationary phase was created by applying NH2-Ni/Co-L-hydroxyproline and Zn-NH2-BDC-D-(+)-glucose onto the silica gel surface using the"mesh coating method".The results showed that 19 chiral drugs and 5 site isomers were separated by NH2-Ni/Co-L-hydroxyproline chiral column,and 6 chiral drugs and 3 site isomers were baseline separated.Ten chiral drugs and three site isomers were separated by Zn-NH2-BDC-D-(+)-glucose-colored chiral spectrum.Both chiral columns have good repeatability.
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