Impurities Spectra of Naringin Products from the Abscission Fruits of Citrus Maxima(Burm.)Merr
Naringin is a kind of flavonoid with multiform usages.The impurities were isolated and identified from the alkali extraction and acid precipitation process of naringin.Repeated recrystallization,column chromatography,preparative and semipreparative HPLC was employed for isolation and purification.Then the purified impurities were identified by NMR and CD spectra.The twelve impurities were obtained and determined as Bergaptol(1),7-Hydroxy-1-benzopiran-2-one(2),Marmin(3),Protocatechuic acid(4),8-(6,7-dihydroxy-3,7-dimethyloct-1-en-3-yl)-5-hydroxy-6,7-furocoumarin(5),Obacunone(6),Naringin(7),7,4'-Dihydroxyflavone(8),Rhoifolin(9),Vicenin(10),Neoeriocitrin(11)and 2S-Neoeriocitrin(12).The above twelve impurities will help to establish quality control standards of naringin based on alkali extraction and acid precipitation process.
naringinalkali extraction and acid precipitation processcoumarinsflavonoidsimpurities
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