Simultaneous Determination of Five Disinfection Byproducts and Perchlorate in Drinking Water by Isotope Internal Standard Dilution UPLC-MS/MS Method
An isotope dilution technique coupled with ultra-performance liquid chromatography-tandem mass spectrometry(ID-UPLC-MS/MS)method was established for simultaneous determination of disinfection byproducts such as dichloroacetic acid,trichloroacetic acid,chlorate,chlorite,bromate,and perchlorate in drinking water.The samples were separated by Torus DEA column(100 mm×2.1 mm,1.7 μm),eluted with 0.5％ammonia-l mmol/L ammonium acetate and acetonitrile as mobile phases,determined by multiple reaction monitoring(MRM)negative mode(ESI-),and quantified by internal standard method.The linear correlation coefficients for all six compounds were greater than 0.990.The detection limits was 1.5～2.1 μg/L,and the quantitation limits was 5.0～7.0 μg/L.The detection rate was 16.04％in 399 water samples.The method involves direct injection of samples using isotope internal standard dilution,resulting in fast analysis speed,high sensitivity,and accurate data.This method is suitable for detecting compounds within the limits set by the drinking water national standards(GB/T 5750.5-2023 and GB/T 5750.10-2023).
drinking waterultra performance liquid chromatography-tandem mass spectrometrydisinfection byproductsperchloratetorus DEA columnisotope internal standard dilution
万方数据
维普
