首页|环氧丁烷开环胺解合成β-氨基醇

环氧丁烷开环胺解合成β-氨基醇

Synthesis of β-Amino Alcohol by Ring Opening Amination of Epoxybutane

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为绿色高效地合成 β-氨基醇类化合物,本工作以环氧丁烷和戊胺为原料,合成了一种具有大基团的β-氨基醇,并对化合物结构进行了表征.研究发现,环氧丁烷和戊胺可以在去离子水溶剂中高效合成β-氨基醇,当环氧丁烷和戊胺的物质的量比为 1:15,在去离子水溶剂体系中室温下反应 3 h,β-氨基醇的产率可达87%左右.环氧丁烷在无催化剂情况下的开环胺解合成β-氨基醇过程简便,产物选择性好,是一种合乎"绿色化学"、对环境友好的β-氨基醇制备技术.
For green and efficient synthesis of β-amino alcohol compounds,a β-amino alcohol with a large functional group was synthesized using epoxybutane and pentamine as raw materials and its structure was characterized in this paper.It was found that the β-amino alcohol could be efficiently synthesized by the reaction of epoxybutane and pentamine in deionized water solvent.The yield of the β-amino alcohol was about 87%when the molar ratio of epoxybutane to pentamine was 1:15 and the reaction was carried out at room temperature in a deionized water solvent system for 3 h.The ring opening aminolysis of epoxybutane to β-amino alcohol without catalyst was easy to operate and showed good product selectivity,which was an environmentally friendly preparation technology of β-amino alcohol belonging to the category of"green chemistry".

epoxy butanepentylamineβ-amino alcoholring opening amination

孙艳荣、马利国、张志鹏、李赛松、李冬至、申鹏、李双雯

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北华航天工业学院材料工程学院,河北省热防护材料重点实验室,河北 廊坊 065000

环氧丁烷 戊胺 β-氨基醇 开环胺解

河北省省级科技计划-中央引导地方科技发展资助项目

216Z1005G

2023

化学反应工程与工艺
联合化学反应工程研究所 ,中石化上海石油化工研究院

化学反应工程与工艺

CSTPCD
影响因子:0.392
ISSN:1001-7631
年,卷(期):2023.39(5)
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