Process Study on Continuous Synthesis of ε-Caprolactone in Microchannel Reactor
ε-Caprolactone was synthesized by Baeyer-Villiger oxidization from cyclohexanone and peroxypropionic acid in a continuous flow microchannel reactor.The effects of reaction temperature,residence time,reactants molar ratio and pipe diameter were investigated for the synthesis of ε-caprolactone.The experimental results showed that under the conditions of reaction temperature at 80℃,residence time of 40 min,molar ratio of peroxypropionic acid to H2O2 of 1.17,pipe diameter between 900-2 000 μm,conversion of cyclohexanone and yield of ε-caprolactone reached 99%,but the content of peroxy acid in product was still relatively high.Preliminary exploration of non-distributed feeding process of peroxypropionic acid showed better process results.Comparing with the traditional batch reaction process,the selectivities and yields of target products in this continuous microchannel reaction process were increased with shortened reaction time,and process continuity ensured higher operation safety.
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