Preparation of Supramolecular Nanomedicine Based on Host-Guest Interaction Between Camptothecin and Cyclodextrin
To improve the poor water solubility of camptothecin and prevent the significant reduction in its anti-cancer effects caused by ring-opening under physiological conditions,a self-assembled supramolecular nanomedicine based on the host-guest interaction of camptothecin and β-cyclodextrin was designed and prepared in this work,and the effects of different water addition rates and polymerization degree of camptothecin on the construction of self-assembled nanomedicine were explored.The results showed that polycamptothecin with polymerization degrees of 5,10,and 20 was obtained by controlling the ratio of monomers and initiators.At the same time,β-cyclodextrin with azide group was designed and synthesized,and the cyclodextrin was grafted to the end of hyaluronic acid by efficient Click reaction.In the end,supramolecular nanomedicine was self-assembled by the host-guest interaction between camptothecin and cyclodextrin.The slow acceleration of water droplets is conducive to self-assembly to form dispersed and uniform particles.It provides some reference significance for the design of nanomedicine in the future.
万方数据
维普
