Loop reactors are widely applied in industries because of good characteristics of gas-liquid in-teraction,and a series of internals are developed and equipped with the reactor to further reinforce the in-teraction.The installation of a contraction-expansion partition between two stages in a two-stage airlift loop reactor can effectively reduce the reversed liquid flow between the stages,while it increases the flow resistance.To pinpoint the effect of width and height of the partition on flow dynamics and obtain the par-tition which can reduce the flow resistance while decrease the reversed liquid flow,this study conducts an optimization of the partition utilizing CFD-PBM and multi-objective optimization methods.Firstly,a se-ries of numerical simulation-based experiments with various partitions at three different superficial gas ve-locities are conducted to obtain the pressure drop and the reversed liquid flow in the two-stage loop reac-tor.It is found that the width and height of the partition as well as superficial gas velocities lead to differ-ent performance of flow dynamics.The width has a greater effect on pressure drop than the height at a low superficial gas velocity,while the effect of height on the pressure drop becomes larger as the superficial gas velocity increases and width is the determinant factor for the reversed liquid flow at all superficial gas velocities in the study.The correlations for pressure drop and the reversed liquid flow with the width and height of the partition are obtained by data fitting.The Pareto fronts for the structure of partition at vari-ous superficial gas velocities are obtained using multi-objective optimization with the pressure drop and the reversed liquid flow as the optimization objectives and the width and height of the partition as optimi-zation parameters.