The airlift loop reactor is widely used in chemical industry,environment and other fields.It is important to study the gas-liquid two-phase flow behavior in the airlift loop reactor to improve its mass transfer performance.In this study,the gas-liquid two-phase flow model and bubble population balance model were developed to investigate the effects of a single square draft tube,a single circular draft tube and six circular draft tubes on the gas-liquid two-phase flow characteristics,bubble size distribution and gas-liquid mass transfer.The results show that the airlift loop reactor with six circular draft tubes has lar-ger average gas holdup and smaller bubble size,thus providing improved mass transfer rate.The relevant simulation results are useful for the structural optimization and scale-up of the airlift loop reactor.