The Multi-Reference Frame(MRF)method is commonly used in the numerical investigation of mixing process,however,the discussion on the size of the rotational domain is not well developed.Nu-merical simulations of the stirring process in a Rushton impeller mixing tank were carried out.By com-pared with experimental results,the optimum inner zone size was determined,and discussion on the height of the inner zone was complemented.In addition,the basis for dividing the rotating inner zone ap-plicable to different mixing cylinder structures was proposed.The results show that the influence of the interface position is mainly in the direction of the impeller discharge flow,and the influence of the inner zone on the torque calculation is less than 5%.The proposed definition of inner domain diameter Z=(din-D)/(T-2b-D)can be applied to mixing equipment of different structures,the accuracy of nu-merical simulations is highest when the inner zone is delineated at Z=0.29,which can provide a theo-retical reference for the selection of the rotating zone size under the MRF method.