Integrated DNA storage system for massive digital data
With the advent of the big data era,the total amount of digital data generated in the world has grown explosively.Due to the natural advantages of extremely high theoretical storage density and long storage time,DNA is considered to provide stable and low-cost storage for massive data.Since the con-cept was proposed,DNA storage technology has made progress in core aspects such as encoding and de-coding algorithms,data recovery and repetitive reading.However,it is still difficult to imagine how the information storage technology based on biomolecular DNA can realize large-scale and stable digital infor-mation storage.There is a huge gap between the storage capacity of any reported DNA information storage prototype system and the actual information storage demand.Therefore,in order to realize practical infor-mation storage of DNA molecules,in addition to solving the problem of core synthesis cost,there is still a lack of technology for stable preservation and high integration of DNA stored in different files,and when faced with massive data storage,it is necessary to design appropriate indexes for DNA libraries to achieve specific file retrieval,and how to interface with existing electronic systems for DNA biomolecule storage devices.This review focuses on the impact of storage methods on the physical storage density of DNA and file retrieval methods,and introduces the methods of file retrieval and research progress in the develop-ment of automated equipment,in order to promote DNA with high physical storage density and convenient file selective retrieval and development of storage systems to facilitate commercial applications of integrat-ed DNA data storage.
DNA information storagedata retrievaldevice integrationDNA preservationpreservation medium
NETL
NSTL
万方数据
