α-Amino ketones are important pharmaceutical molecules and highly active reaction intermediates.Using 2-(phenylethy-nyl)benzaldehyde and N-benzoyl imine precursor as starting materials,an aza-benzoin condensation catalyzed by a thiazole-derived N-heterocyclic carbene was conducted,synthesizing eight differently substituted 2-benzamido-2-phenyl-1-(2'-phenylethynyl)phenyl ethan-1-one 4 with yields ranging from 56％to 91％.The structure of product 4 was identified by 1 H NMR,13C NMR and HRMS.To verify the practicality of the reaction,a scale-up experiment was performed for the synthesis of 4g,yielding 85％.This reaction was characterized by mild conditions,a broad substrate scope,simple procedures,and high yields,providing a valuable reference for in-dustrial applications.
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