Green synthesis of fused multicyclic tetrahydroquinoline-iminosugars
Tetrahydroquinolines have good biological activities,and the"sugar-like"structural features of the polyhydroxyl groups on the azaglycan ring give tetrahydroquinoline azaglycan thickened compounds potential applications in the field of new drug discovery and development.In this paper,a series of novel fused multicyclic iminosugars were synthesized in a simple one-step stereoselective manner at room temperature by the aza Diels-Alder reaction mechanism using D-ribose tosylate and arylamine as raw materials.The reaction was able to produce the expected products with substituents in the m-or p-positions aniline.The reaction was characterized by mild conditions,simple operation,high yield and metal-free catalysis.
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