Employing({ 4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl} methyl)(triphenyl)phosphonium bromide as raw material,via the reaction of condensation,hydrolysis and calcification,the rosuvastatin calcium salt was.The synthesis process was systematically studied in this paper,avoiding occurring racemization reaction in the hydrolysis path-way,which could increase the purity of the targeted product and the quantity of API of rosuvastatin calcium salt.This new developed protocol resulted in the over 80％total yield and 99.5％purity for rosuvastatin calcium salt,and the percentage of the diastereoiso-mers and other impurities were less than 0.1％.
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