Latest Findings on the Role of α-Ketoglutarate in Metabolic Syndrome
Alpha-ketoglutarate(α-KG),an endogenous intermediate of the tricarboxylic acid cycle,is involved in a variety of cellular metabolic pathways.It serves as an energy donor,a precursor of amino acid biosynthesis,and an epigenetic regulator.α-KG plays physiological functions in immune regulation,oxidative stress,and anti-aging as well.In recent years,it has been reported that the level of α-KG in the body is closely associated with metabolic syndrome,including obesity,hyperglycemia,and other pathological factors.Exogenous supplementation of α-KG improves obesity,blood glucose levels,and cardiovascular disease risks associated with metabolic syndrome.Furthermore,α-KG regulates the common pathological mechanisms of metabolic syndrome,suggesting the potential application prospect of α-KG in metabolic syndrome.In order to provide a theoretical basis for further exploration of the application of α-KG in metabolic syndrome,we focused on α-KG and metabolic syndrome in this article and summarized the latest research progress in the role of α-KG in improving the pathological condition and disease progression of metabolic syndrome.For the next step,researchers may focus on the co-pathogenesis of metabolic syndrome and investigate whether α-KG can be used to achieve the therapeutic goal of"homotherapy for heteropathy"in the treatment of metabolic syndrome.
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