Effects of the extract from Dipsacus asperoides on learning and memory ability and its protection on hippocampal neuron of vascular dementia in rats
OBJECTIVE To investigate the effects of the extract from Dipsacus asperoides (EDA) on learning and memory ability and hippocampal neuron of vascular dementia in rats.METHODS Vascular dementia (VD) model in rats was established by common carotid artery repeatedly occlusion and sodium nitroprussideip injection.The learning and memory ability,activities of SOD,MDA,GSHPx and Bcl-2 and Bax protein in hippocampus of VD rats were measured.RESULTS Compared with the model group,middle and high does D.asper could improve the learning and memory ability,activities of SOD,GSH-Px in the blood and Bcl-2 protein in the hippocampus,and also inhibit MDA in the blood and Bax protein expression protein in the hippocampus of VD rats.CONCLUSION EDA can improve memory impairment and it certainly has a protective effect on hippocampal neurons of Vascular Dementia rats.
Dipsacus asperoidesVascular dementiaLearning and memoryHippocampal neuronFree radicalsApoptosisBcl-2 proteinBax protein
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万方数据
维普
