Study on antibacterial ophthalmice hydrogel loaded with copper ion self-assembled peptide in vitro
OBJECTIVE To prepare a self-assembled peptide antimicrobial ophthalmic hydrogel ligated to copper ions.METHODS(RADA)4 self-assembled peptide was rapidly mixed with CuCl2 aqueous solution to form a stable(RADA)4@Cu2+hydrogel.The hydrogels were characterised by SEM,EDS,FTIR and UV-Vi photometric properties.The antibacterial properties of hydrogel were investigated against Staphylococcus aureus and Escherichia coli,as well as the biocompatibility of the hydrogel with human corneal epithelial cells.RESULTS(RADA)4@Cu2+hydrogel had good antibacterial properties and biocompatibility.CONCLUSION It lays the foundation for the application study of ophthalmic gels.
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