Therapeutic effect of a novel oral gel on gingivitis in rats
OBJECTIVE To study the therapeutic effect of a novel oral gel on gingivitis in rats.METHODS Gingivitis model was induced in healthy SD rats by ligating the left maxillary second molar(M2)with orthodontic steel wire and feeding with 10％high sugar water-soaked diet daily for two weeks.The successful models were chosen and randomly divided into model control group and oral gel group,and another normal control group was set up without any treatment.After 7 days of treatment,clinical indices such as probing depth,sulcus bleeding index and gingival index were observed in rats.IL-6 and IL-1 β mRNA contents were detected by q-PCR and gingival histopathological changes were examined by HE staining.RESULTS After 7 days of treatment,the oral gel group showed a significant reduction in gingival redness and swelling,a decrease in probing depth,sulcus bleeding index,and gingival index,as well as a significant reduction in the mRNA expression levels of IL-6 and IL-1β,and a significant improvement in gingival tissue edema when compared to the model group.CONCLUSION The oral gel improves clinical gingivitis indicators and alleviates experimental gingivitis symptoms in rats.
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