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百合的化学成分研究

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目的 研究百合的化学成分.方法 以鲜百合Lilium brownii为对象,采用正相硅胶柱色谱、ODS反相色谱、半制备液相等色谱技术分离纯化其醇提物的乙酸乙酯和正丁醇部位,利用核磁共振波谱法鉴定所得单体化合物的结构.结果 从百合中分离得到 10 个化合物,鉴定为:1,5-dihydro-3-methyl-3H-pyrrol-2-one(Ⅰ)、(R)-4-(2,4-dihydroxy-3,3-dimethyl-butyrylamino)-butyric acid(Ⅱ)、反式肉桂酸(Ⅲ)、丙三醇(Ⅳ)、二甘醇(Ⅴ)、胸苷(Ⅵ)、丁香脂素(Ⅶ)、松脂素(Ⅷ)、表松脂素(Ⅸ)、isonuatigenin(Ⅹ).结论 化合物Ⅳ～Ⅹ为首次从中药百合中分离得到,其中,化合物Ⅶ～Ⅹ为首次从百合属植物中分离得到.
Study on the chemical constituents from the bulbs of Lilium brownii
OBJECTIVE To investigate the chemical constituents of the bulbs of L.brownii.METHODS Fresh L.brownii was used as the subject.Modem chromatographic techniques,including normal-phase silica gel column chromatography,ODS reversed-phase chromatography,and semi-preparative liquid chromatography,were employed to isolate and purify the chemical constituents from the ethyl acetate and n-butanol fractions of the alcohol extract.The structures of the isolated compounds were determined using nuclear magnetic resonance spectroscopy.RESULTS Ten compounds were isolated from the bulbs of the lilium and identified as 1,5-dihydro-3-methyl-3H-pyrrol-2-one(Ⅰ),(R)-4-(2,4-dihydroxy-3,3-dimethyl-butyrylamino)-butyric acid(Ⅱ),trans-cinnamic acid(Ⅲ),glycerol(Ⅳ),diglycerol glycol(Ⅴ),thymidine(Ⅵ),syringaresin-ol(Ⅶ),pinoresinol(Ⅷ),epipinoresinol(Ⅺ)and isonuatigenin(Ⅹ).CONCLUSION Compounds Ⅳ-Ⅹare isolated from L.brownii for the first time,while compounds Ⅶ-Ⅹ are isolated for the first time from the Lilium genus.

LiliaceaeLilium browniiChemical compositionExtraction and isolationStructural identificationNMRReversed-phase preparative liquid chromatographyLignans

贺帅博、张丽萍、魏文君、郭涛

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河南中医药大学药学院,河南郑州4500462

百合科 百合 化学成分 提取分离 结构鉴定 核磁共振波谱法 反向制备色谱 木脂素

2022年度省级科技研发计划联合基金张仲景传承与创新专项

222301420075GZY-KJS-2022-048-3

2024

10.13375/j.cnki.wcjps.2024.02.003

华西药学杂志
四川大学,四川省药学会

华西药学杂志

CSTPCD北大核心
影响因子：0.624
ISSN：1006-0103
年,卷(期)：2024.39(2)
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