榜那的研究进展及质量标志物的预测分析
Research progress of Bangna and predictive analysis on quality-marker
朱可欣 1阳勇 1周莹莹 1胡前梅 1张小梅 2达娃卓玛 3钟国跃 4熊永爱5
作者信息
- 1. 遵义医科大学药学院,贵州遵义 563000;重庆市中药研究院,重庆 400065
- 2. 重庆市中药研究院,重庆 400065
- 3. 西藏自治区食品药品检验研究院国家药品监督管理局中药(藏药)质量控制重点实验室,西藏拉萨 850000
- 4. 江西中医药大学,江西南昌 330004
- 5. 遵义医科大学药学院,贵州遵义 563000
- 折叠
摘要
榜那为藏医常用药材,主要成分生物碱具有抗炎、镇痛、抗肿瘤、抗菌等药理作用.现在总结榜那化学成分和药理作用的基础上,结合其质量控制研究进展,以质量标志物(Q-Marker)的理论为指导,从亲缘关系、传统药性、药效、炮制、成分方面对Q-Marker进行预测,分析发现伏毛铁棒锤Aconitum flavum Hand.-Mazz.和铁棒锤A.pendulum Busch.比较接近,而与工布乌头A.kongboense Lauener.有较大差异,提示乌头碱可作为伏毛铁棒锤或铁棒锤的Q-Marker,塔拉萨敏可作工布乌头的Q-Marker,为榜那质量评价体系的建立及开发利用提供了参考.
Abstract
Bangna is a Tibetan conventional herbs.Its main composition are alkaloids with various function including anti-inflammatory,analgesic,anti-tumor,antibacterial and other pharmacological effects.We summarized the chemical components and pharmacological effects of bangna by using the quality marker(Q-Marker)as the prediction standard from genetic relationship,traditional medicinal properties,efficacy,processing,and components on the basis.Based on that,we found Aconitum flavum Hand.-Mazz.,A.pendulum Busch were close to each other,but different from A.kongboense Lauener.According to the findings,aconitine can be utilized as quality marker of A.flavum.and A.pendulum,talasamine can be utilized as quality marker of A.kongboenseLauener.It serves as a roadmap for the creation and further advancement of a more rational and scientific quality evaluation system for Bangna and directs clinical application.
关键词
榜那/铁棒锤/伏毛铁棒锤/工布乌头/质量标志物/二萜类生物碱/乌头碱/塔拉萨敏Key words
Bangna/Aconitum pendulum Busch./Aconitum flavum Hand.-Mazz./Aconitum kongboense Lauener./Q-markers/Diterpenoid alkanoids/Aconine/Talatisamine引用本文复制引用
基金项目
国家重点研发计划项目(2019YFC1712300)
中国药品监管科学行动计划第二批重点项目(NMPAJGKX-2023-080)
出版年
2024
NETL
NSTL
万方数据