Study on chemical compositions of Astragalus prattii and its anti-Alzheimer's disease properties through Network pharmacology
OBJECTIVE To study the chemical compositions of Astragalus prattii Simps and to explore the mechanism against Alzheimer's disease(AD)through network pharmacology.METHODS The ethanol extract of A.prattii was separated and purified by silica gel column chromatography and preparation chromatography.The chemical compositions were identified by NMR and GC-MS.The potential active ingredients and core targets of A.prattii.against AD were screened by Network pharmacology,then biological function enrichment analysis based on core targets.RESULTS TA total of 43 compounds were identified from the ethanol extract of A.prattii including flavonoids,triterpenoids,esters,phenolic acids and other compounds.33 potential active components were selected,which mainly exert anti-AD effects by regulating pathways such as neurodegenerative diseases,c-AMP signaling pathway,and PI3K-Akt signaling pathway.CONCLUSION This study enriches the chemical composition information of A.prattii,and provides a scientific theoretical basis for the research of A.prattii against AD.
AstragalusAstragalus prattii SimpsExtraction and separationAlzheimer's diseaseNetwork pharmacology
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NSTL
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