丙酸氟替卡松经鼻缓释膜的处方筛选和体外释放研究
Formulation screening and in vitro release study of Fluticasone propionate transnasal sustained-release films
陶婉君 1尹善美 2王胜杰 2黄瑜 3尹宗宁2
作者信息
- 1. 电子科技大学医学院附属妇女儿童医院·成都市妇女儿童中心医院,四川成都 611731;四川大学华西药学院,四川成都 610041
- 2. 四川大学华西药学院,四川成都 610041
- 3. 海思科医药集团股份有限公司,四川成都 611100
- 折叠
摘要
目的 优化丙酸氟替卡松经鼻缓释膜的处方,研究其释放度.方法 通过单因素实验筛选聚乳酸-羟基乙酸共聚物(PLGA)的种类和用量、增塑剂的种类和用量、载药量和成膜溶剂;通过正交试验优化丙酸氟替卡松经鼻缓释膜的处方.结果 丙酸氟替卡松经鼻缓释膜的最佳处方为:PLGA85/15(特性黏数0.65～0.75 dL·g-1)用量为17.62 mg·cm-2,丙酸氟替卡松的载药量4.75 mg·cm-2,增塑剂PEG400的用量0.78 mg·cm-2,溶剂为丙酮.结论 丙酸氟替卡松经鼻缓释膜可缓慢释放丙酸氟替卡松12周,具备良好的长效缓释性能.
Abstract
OBJECTIVE To optimize the formulation of Fluticasone propionate transnasal sustained-release films and to study its release.METHODS Through single factor experiments,the types and dosage of poly(lactic-co-glycolic acid)(PLGA),the types and dosage of plasticizers,drug loading,and film forming solvents were selected.The optimal prescription of Fluticasone propionate transnasal sustained-release film was selected by Orthogonal experiments.RESULTS The optimal formulation for the transnasal sustained-release film of Fluticasone propionate is PLGA85/15(intrinsic viscosity was 0.65-0.75 dL·g-1)with a dosage of 17.62 mg·cm-2,fluticasone propionate loading at 4.75 mg·cm-2,PEG400 as a plasticizer at 0.78 mg·cm-2,and the solvent was acetone solution.CONCLUSION Fluticasone propionate is slowly released through the transnasal sustained-release film for 12 weeks,exhibiting good long-term sustained-release performance.
关键词
丙酸氟替卡松/慢性鼻窦炎/缓释/膜剂/聚乳酸-羟基乙酸共聚物/正交试验/增塑剂/十二烷基硫酸钠Key words
Fluticasone propionate/Chronic sinusitis/Sustained release/Films/Poly(lactic-co-glycolic acid)/Orthogonal experiment/Plasticizers/Sodium dodecyl sulfate引用本文复制引用
出版年
2024
NETL
NSTL
万方数据