Formulation screening and in vitro release study of Fluticasone propionate transnasal sustained-release films
OBJECTIVE To optimize the formulation of Fluticasone propionate transnasal sustained-release films and to study its release.METHODS Through single factor experiments,the types and dosage of poly(lactic-co-glycolic acid)(PLGA),the types and dosage of plasticizers,drug loading,and film forming solvents were selected.The optimal prescription of Fluticasone propionate transnasal sustained-release film was selected by Orthogonal experiments.RESULTS The optimal formulation for the transnasal sustained-release film of Fluticasone propionate is PLGA85/15(intrinsic viscosity was 0.65-0.75 dL·g-1)with a dosage of 17.62 mg·cm-2,fluticasone propionate loading at 4.75 mg·cm-2,PEG400 as a plasticizer at 0.78 mg·cm-2,and the solvent was acetone solution.CONCLUSION Fluticasone propionate is slowly released through the transnasal sustained-release film for 12 weeks,exhibiting good long-term sustained-release performance.
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