血康胶囊的成分分析及其抗原发免疫性血小板减少症的作用

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中文摘要：目的分析血康胶囊提取物的主要化学成分,探讨其治疗原发免疫性血小板减少症(ITP)的药效.方法利用高分辨四极杆飞行时间串联液质联用仪测定血康胶囊提取物中的化学成分;ip给予BALB/C小鼠50 μg·kg-1大鼠抗小鼠整合素GPⅡb/CD41建立原发免疫性血小板减少症模型,记录小鼠给药前后的体重变化及死亡情况,并对血常规变化进行分析.结果从血康胶囊提取物中共鉴定出有机酸、香豆素、萜类、黄酮类等4种主要成分.与模型组比较,血康胶囊提取物组小鼠的外周血小板和白细胞数目均有显著差异.结论血康胶囊提取物能显著提高ITP模型小鼠的血小板数目,对原发免疫性血小板减少症有显著疗效.

外文标题：Composition analysis of Xuekang capsules and its effects on primary immune thrombocy-topenia

外文摘要：OBJECTIVE To analyze the main chemical components of Xuekang capsule extracts and to explore its efficacy in the treatment of primary immune thrombocytopenia(ITP).METHODS The chemical constituents in Xuekang capsule extracts were identified by LC-MS.ITP model was established by intraperitoneal injection of 50 μg·kg-1 rat anti-mouse integrin GPⅡb/CD41 for BALB/C mice.The changes of body weight and death of mice before and after administration were recorded,and the changes of blood routine were analyzed.RESULTS Four main chemical components of organic acids,coumarins,terpenoids and flavonoids were identified form Xuekang capsule extracts.The number of peripheral platelets and white blood cells in the Xuekang capsule extract groups were significantly different from those in the model group.CONCLUSION Xuekang capsule extracts can significantly increase the number of platelets and has a significant effect on ITP.

外文关键词：

Xuekang capsule extractsLiquid chromatography-mass spectrometryChemical compositionPrimary immune thrombocytopeniaRat anti-mouse integrin GPⅡb/CD41Drug efficacy study

作者：

计嘉韵、胡江宁、李茜茜、沈梦丹、吴素香、石森林、张婷

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作者单位：

浙江中医药大学药学院,浙江杭州 310052

浙江现代中药与天然药物研究院有限公司,浙江杭州 310052

关键词：

血康胶囊提取物液质联用化学成分原发免疫性血小板减少症大鼠抗小鼠整合素GPⅡb/CD41 药效研究

基金：

浙江省自然科学基金

项目编号：

LY21H280004

出版年：

2024

DOI：

10.13375/j.cnki.wcjps.2024.03.009

华西药学杂志

四川大学,四川省药学会

华西药学杂志

CSTPCD北大核心

影响因子：0.624

ISSN：1006-0103

年,卷(期)：2024.39(3)