首页|近红外光谱法检测复方甘草酸苷制剂的质量

近红外光谱法检测复方甘草酸苷制剂的质量

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
目的 采用近红外光谱技术结合化学计量学快速检测复方甘草酸苷制剂的质量.方法 利用标准正态变量变换和二阶导数进行预处理;分别采用连续投影算法、遗传算法和竞争自适应重加权算法对特征波长进行筛选;对筛选后的特征波长建模,并比较模型效果.结果 竞争自适应重加权算法筛选后的波长建模效果最好,甘草酸苷、盐酸半胱氨酸、甘氨酸的含量预测模型的测定系数分别为0.9501、0.9522、0.9549,校正标准偏差分别为0.482、0.502、0.544,预测标准偏差分别为0.689、0.732、0.832.预测值可显著解释测量值.结论 竞争自适应重加权算法的预测效果较好,结果可靠,可用于快速检测复方甘草酸苷制剂的质量.
Quality study of Compound glycyrrhizin preparation by Near-infrared spectroscopy
OBJECTIVE To rapidly detect the quality of Compound glycyrrhizin preparations by Near-infrared spectroscopy and chemometric methods.METHODS This study focuses on Compound glycyrrhizin preparations and employs standard normal variate transformation and second-derivative preprocessing.The research involves a combination of techniques,including the successive projection algorithm,the genetic algorithm,and the competitive adaptive reweighted sampling.These methods are applied for feature wavelength selection and modeling,enabling a comparative assessment of model performance.RESULTS The competitive adaptive reweighted sampling demonstrated superior performance in feature wavelength selection,resulting in highly accurate models for the prediction of glycyrrhizin,cysteine hydrochloride,and glycine content.The determination coefficients for these models were 0.9501,0.9522,and 0.9549,while the root mean square error of calibration values were 0.482,0.502,and 0.544,and the root mean square error of prediction values were 0.689,0.732,and 0.832,respectively.External validation results further confirmed the significant explanatory power of the predictive models in relation to the measured values.CONCLUSION The competitive adaptive reweighted sampling demonstrates superior predictive performance,yielding reliable results suitable for the rapid quality assessment of Compound glycyrrhizin preparations.

Compound glycyrrhizinNear-infrared spectroscopySpectra pretreatmentSuccessive projections algorithmGenetic algorithmCompetitive adaptive reweighted samplingQuality control

童一洋、郭志永、闻宇、李杰、薛洪宝、李楠楠、殷晓建

展开 >

蚌埠医科大学公共基础学院,安徽蚌埠 233030

安徽宏业药业有限公司生产技术部,安徽蚌埠 233045

安徽省药品监督管理局第五分局,安徽蚌埠 233000

复方甘草酸苷 近红外光谱 光谱预处理 连续投影算法 遗传算法 竞争自适应重加权算法 质量控制

安徽省高等学校学科(专业)拔尖人才学术项目安徽省新时代育人质量工程研究生教育项目

gxbjZD20220412022lhpysfjd0612022sshqygzz033

2024

10.13375/j.cnki.wcjps.2024.03.018

华西药学杂志
四川大学,四川省药学会

华西药学杂志

CSTPCD北大核心
影响因子：0.624
ISSN：1006-0103
年,卷(期)：2024.39(3)